The European champion clocked 9.97 seconds at Hayward Discipline to complete second in his warmth, behind favorite Fred Kerley.
Hughes, who reached final yr’s Olympic closing solely to false begin, expects drama on Saturday after seven sprinters ran sub-10 seconds within the heats.
“It’s a extremely quick monitor. It’s actually thrilling. What excited me was when the F18s flew over the stadium, that acquired me gassed up,” mentioned the 27-year-old, who certified fifth quickest.
“Kerley ran 9.79 seconds, I believe it’s the quickest ever within the heats. There have been some good names in there however I’m not specializing in names, I’m not specializing in instances. Put what occurred within the season behind. What issues right here issues.
“I mentioned at trials I used to be OK, I simply should belief myself, belief my pace. My coach has been telling me ‘don’t fear in regards to the begin, simply give attention to what must be performed, execute it and also you’ll be OK.’
“I didn’t panic. Su (Bingtain) is a good starter, the opposite guys are nice starters and I’ve by no means been the most effective starter on this planet.”
Prescod ran 10.15 seconds to complete fourth within the fourth warmth however was unable to clinch a qualifying spot in a shock elimination.
Africa’s quickest man Ferdinand Omanyala received his race towards the clock to line up in warmth seven. He suffered visa points forward of his journey to Oregon and solely landed hours earlier than his race and certified third.
Defending champion, the USA’s Christian Coleman again after his ban for lacking medicine checks, ran 10.08 seconds as he slowed down on the road.
Within the pole vault, Holly Bradshaw retired after a freak incident within the heat up noticed her pole break and he or she landed awkwardly on the again of her neck.
She was helped away from the mat and opted to give up after experiencing some discomfort.
Laura Muir eased into Saturday’s 1500m semi-final with a managed race to complete second behind Ethiopia’s Hirut Meshesha.
Muir sat in the back of the pack for the opening two laps earlier than making her transfer and clocked 4 minutes 07.53 seconds. Katie Snowden additionally progressed, whereas Melissa Courtney-Bryant fell kind.
Amy Strickler threw 17.40m and Sophie McKinna 17.21m however they failed to achieve the shotmput closing.
Earlier, Nice Britain missed out on a spot within the closing of the blended 4x400m relay.
Joe Brier, Zoey Clark, Alex Haydock-Wilson and Laviai Nielsen clocked three minutes 14.75 seconds to complete sixth of their warmth and ninth quickest.
The Dominican Republic received Friday night’s closing – the primary gold of the Championships – forward of the Netherlands and the USA.
Nick Miller certified for Saturday’s hammer closing after coming ninth in pool A, throwing 77.13m however Joel Clarke-Khan was unable to make the excessive bounce after solely clearing 2.21m.