Acupuncture, which comes from conventional Chinese language medication, may assist in the remedy of pathologies associated to Covid-19, as proven by experiments on animals.
By Jean-Marc Sabatier *
Throughout a viral an infection, the SARS-CoV-2 virus induces a dysfunction of the renin-angiotensin system (RAS) by binding to the ACE2 receptor of goal cells. This RAS dysfunction induced by the virus (and even by the vaccine spike protein) leads to the overactivation of its deleterious AT1R receptor current on many organs and tissues.
The overactivated AT1R receptor is accountable for Covid-19 ailments by way of its pro-hypertensive, pro-inflammatory, pro-oxidant, pro-thrombotic, pro-angiogenic, pro-fibrotic, pro-hypertrophic, and nitric oxide manufacturing inhibition actions.
When the RAS and its AT1R receptor are overactivated, there’s a excessive manufacturing of renin (which converts angiotensinogen into angiotensin-1, which is the precursor of angiotensin-2), an extra of angiotensin-2 (which overactivates the RAS and the AT1R receptor), and a launch of aldosterone (by way of the surplus of angiotensin-2).
Extra angiotensin-2 results in activation of the sympathetic nervous system, which controls the physique’s “automated” actions (coronary heart price/respiration, blood circulation, digestion and waste elimination, easy muscle contraction, and so on.) and the functioning of organs (kidneys, digestive system, and so on.). Chemical mediators of this method, corresponding to adrenaline and noradrenaline, enable exact management of those capabilities.
Activation of the sympathetic nervous system could be accompanied by cardiac (tachycardia) or intestinal disturbances, hypertension/vasoconstriction of blood vessels, dilation of the bladder and/or bronchial tubes, elevated sweating, launch of glucose by the liver, extra secretion of adrenaline and noradrenaline by the adrenal glands, and others.
Acupuncture in animals
Surprisingly sufficient, it has been demonstrated experimentally in animals that acupuncture (an empirical technique of care primarily based on using needles stimulating particular factors on the pores and skin), or low frequency electro-acupuncture from 2 to 30 Hz (a variant of acupuncture permitting the supply of weak electrical currents by means of the pores and skin), and even moxibustion (it consists in stimulating an acupuncture level by way of warmth utilizing moxas), was in a position to act on hypertension and metabolic homeostasis of many key molecules instantly or not directly concerned within the RAS and Covid-19 ailments (for instance : renin, angiotensin-2, aldosterone, endothelin-1, nitric oxide, dopamine, serotonin, norepinephrine, enkephalins/endorphins, and so on. ).
These information counsel that acupuncture -an ancestral method from conventional Chinese language medicine- could possibly be an strategy of curiosity for the remedy or potential reduction of pathologies associated to Covid-19, and extra significantly to Covid lengthy.
*Jean-Marc Sabatier is Director of Analysis on the CNRS and holds a PhD in Cell Biology and Microbiology. Editor-in-Chief of the worldwide scientific journals: “Coronaviruses” and “Infectious Problems – Drug Targets”. He speaks right here in his personal title.